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User agents may provide users the option of disabling the window.performance.timing and window.performance.navigation interfaces. When these interfaces are disabled, both window.performance.timing and window.performance.navigation must return a null value.

Example

A user agent may maintain instances of the PerformanceTiming and PerformanceNavigation interfaces until the Window object associated with the current document is created, when window.performance.timing and window.performance.navigation are replaced with these instances.

Illustration

This illustration is non-normative.

The following graph illustrates the timing attributes defined by the Columbia Buxton Peak™ Mid Waterproof Pictures Cheap Online Low Price Cheap Online Cheap Release Dates TwhQFH
interface and the PerformanceNavigation interface with or without redirect, respectively. Attributes underlined may not be available in navigation involving documents from different Trotters Liz Tumbled Blue Very Soft Leather Womens Slip on Shoes Buy Cheap Really Choice Online Shopping Online Cheap Price AOO797s
. User agents may perform internal processing in between timings, which allow for non-normative intervals between timings.

Return to step 11 if the user agent fails to send the request or receive the entire response, and needs to reopen the connection.

Example

When Tods Slip on Sneakers for Men On Sale Sugar paper suede 2017 10 11 7 85 9 95 Cheap New Styles c24Xc
[ RFC 2616 ] is enabled, a user agent may first try to re-use an open connect to send the request while the connection can be Original Penguin Mens Bruce Mixed Sneakers Brown/Blue Cheap Discount Sale Shop Online etRcK9q
. In such case, connectStart, connectEnd and requestStart should represent timing information collected over the re-open connection.

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from the window object to its window.performance.timing and window.performance.navigation objects.

The value of the timing attributes must monotonically increase to ensure timing attributes are not skewed by adjustments to the system clock during the navigation. The difference between any two chronologically recorded timing attributes must never be negative. For all navigations, including subdocument navigations, the user agent must record the system clock at the beginning of the root document navigation and define subsequent timing attributes in terms of a monotonic clock measuring time elapsed from the beginning of the navigation.

Vendor-specific proprietary user agent extensions are discouraged. If such extensions are needed, e.g., for experimental purposes, vendors must use the following extension mechanisms:

There is the potential for disclosing an end-user's browsing and activity history by using carefully crafted timing attacks. For instance, the unloading time reveals how long the previous page takes to execute its unload handler, which could be used to infer the user's login status. These attacks have been mitigated by enforcing the same origin policy when timing information involving the previous navigation is accessed.

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In its ninth year, the 76-page report covers a range of aviation industry-specific economic and performance data as well as global capacity growth by region. The report also includes discreteanalyses on:

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Stage-length adjusted revenue per available seat

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Airline Economic Analysis 2016-2017

Prior Year Annual Report

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Fig. 3.

Minocycline prevents MPTP-induced MAC-1 transcription. , , Ventral midbrain MAC-1 mRNA levels but not GFAP mRNA levels are increased by 24 hr after MPTP injection compared with those of saline- or minocycline-injected mice. Minocycline prevents MPTP-induced MAC-1 mRNA increases. MAC-1 and GFAP mRNA values are normalized with GAPDH. Values are mean ± SEM ratios ( = 5–7 mice per group)., Saline-treated; minocycline-treated;, MPTP-treated; , MPTP plus minocycline-treated. * < 0.05, higher than both saline- and minocycline-injected control groups. ** < 0.05, lower than MPTP-injected group and not different from both control groups.

Fig. 4.

Minocycline prevents MPTP-induced microglia reaction. Microglia cells () and TH-positive neurons () are seen in both SNpc and striatum of all mice. One day after the last MPTP injection, numerous activated microglia (larger cell body, poorly ramified short and thick processes) are seen in SNpc (, ) and striatum (, ). Mice injected with both MPTP and minocycline show minimal microglial activation in SNpc () and striatum (); here, microglial cell bodies are small and processes are thin and ramified (, ). Scale bar:, , , , 1 mm; , , ,, 100 μm.

Fig. 5.

Minocycline does not affect MPTP-induced astrocytic reaction. One day after the last injection of MPTP, there is a mild astrocytic response (, ), but 7 d after the last injection of MPTP, it becomes conspicuous (, ). Minocycline does not affect the astrocytic response (, ) 7 d after MPTP administration. Scale bar: ,, , 1 mm; ,, , 100 μm.

Given the effect of minocycline on MPTP-induced microglial activation, we assessed whether the production of known microglial noxious mediators such as IL-1β, ROS, and NO will also be inhibited by minocycline (Fig. Low Shipping Sale Online Roberto Cavalli perforated lowtop sneakers Black For Sale Online kv06qQ
). The levels of ventral midbrain IL-1β differed significantly among the four group of mice ( F (3,21) = 7.946; p < 0.001) (Fig. Under Armour Womens UA SpeedForm Apollo Running Shoes Cheap Sale Footlocker Free Shipping Extremely Ebay Sale Online NFud4xP
A ). Ventral midbrain levels of the proinflammatory cytokine IL-1β in MPTP-injected mice (18 mg/kg for four injections) were significantly increased (Fig. Clearance Low Shipping Fee GH Bass amp; Co Patricia Tan Leather Womens Shoes For Sale OzXdW
A ). However, MPTP produced significantly smaller increases in IL-1β levels in ventral midbrain of MPTP mice treated with minocycline (45 mg/kg twice daily) (Fig. 6 A ). iNOS activity ( F (3,24) = 9.055; p < 0.001) and the ratio of membrane/total p67 phox ( F (3,23) = 4.336; p < 0.05) also varied significantly among the various groups. iNOS and NADPH–oxidase, two prominent enzymes of activated microglia that produce NO and ROS, respectively, exhibited induction patterns similar to those described for IL-1β in that ventral midbrain iNOS activity was increased by 200% (Fig. 6 B ) and NADPH–oxidase activation, evidenced by the translocation of its subunit p67 phox from the cytosol to the plasma membrane, was increased by 80% 24 hr after the last injection of MPTP (Fig. 6 C , D ). MPTP-induced iNOS activity and NADPH–oxidase were both abolished by minocycline administration (Fig. 6 B–D ).

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